INFLUENCE OF QUERCETIN AND DIHYDROQUERCETIN ON SOME FUNCTIONAL PARAMETERS OF RAT LIVER MITOCHONDRIA

Flavonoids are proved to be prominent plant-derived compounds generally found in fruit- and vegetable- rich diets with free radicals quenching ability. Quercetin, a member of flavonoids subclass – flavonols, has gained major attention due its overwhelming potential. Quercetin was demonstrated preserve diverse degenerative diseases by inhibiting lipid peroxidation. In the present paper, we deal two polyphenolic compounds’ quercetin dihydroquercetin influence on functional parameters mitochondria. Thus, fore mentioned flavonols showed mitochondrial permeability transition pore (mPTP) inhibition ATP-sensitive potassium channel activation capacities as well strong antioxid?nt/antiradi?al activity. Improving mitochondria both formed basic idea hypothesis that studied may provide antihypoxic defense.